Kun Xie

Multi-Timescale Neural Adaptation Failure as a Mechanistic Signature of Major Depression

This paper identifies neural adaptation failure as a core mechanism of major depression, showing it outperforms traditional measures in classification and provides a scalable biomarker.

Exploring the effect of capsaicin on gene expression and chemotherapy sensitization in gastric cancer cells

This study investigates how capsaicin affects gene expression and enhances chemotherapy sensitivity in gastric cancer cells by inhibiting DNA repair pathways.

Cortical Acetylcholine Response to Deep Brain Stimulation of the Basal Forebrain

This study examines how different DBS parameters affect cortical acetylcholine levels and shows that peak responses are insensitive to frequency but increase with longer stimulation and donepezil treatment.

Telomere-to-telomere, gap-free genome of mung beans (Vigna radiata) provides insights into domestication under structural variation

The paper presents a gap-free genome assembly of mung beans and identifies structural variations and selection pressures during domestication.

Blood pressure variability compromises vascular function in middle-aged mice

This study shows that chronic blood pressure variability impairs vascular function and causes cognitive deficits in middle-aged mice.

3-D optogenetic control of arteriole diameter in vivo

This paper develops an optogenetic method to control arteriole diameter in 3D with high spatiotemporal resolution, enabling study of vascular dynamics and blood flow regulation.

Neural code uses self-information principle to organize the brain’s universal cell-assembly coding

The paper introduces a theory of neural coding based on self-information principles and demonstrates its application in identifying cell-assembly patterns across various brain activities.

Spike-timing pattern operates as gamma-distribution across cell types, regions and animal species and is essential for naturally-occurring cognitive states

The paper shows spike-timing patterns across different neurons and species follow a gamma-distribution, remain stable across cognitive states, and break down under anesthesia.