Kyle Cekada

Circuit regulation along an activity continuum shapes flexible and stable representations during learning

The paper identifies mechanisms in the medial entorhinal cortex that balance representational flexibility and stability during learning through excitatory and inhibitory neuronal activity dynamics.

Functional and structural characterization of dendritic spine pathology in a mouse model of tauopathy

The paper examines how tauopathy affects dendritic spine function and structure in mice, finding that spines in tau mutants are hypoactive and less tuned compared to controls.

The entorhinal spatial map integrates visual identity information of landmarks

This study shows that the medial entorhinal cortex encodes landmark identity through cue cells during navigation, distinct from spatial encoding by grid cells.

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairment

This study links tau pathology in the medial entorhinal cortex to spatial memory impairment by showing dysregulated neural activity and sex-specific resilience in PS19 tauopathy mice.

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

The paper shows that slow hippocampus-to-entorhinal plasticity underlies gradual grid cell map formation and fragmentation in novel environments through longitudinal imaging and modeling.