Yi Gu

Circuit regulation along an activity continuum shapes flexible and stable representations during learning

The paper identifies mechanisms in the medial entorhinal cortex that balance representational flexibility and stability during learning through excitatory and inhibitory neuronal activity dynamics.

Activation of the medial entorhinal cortex drives memory-guided navigation behavior

This study shows that spatially consistent activation of the medial entorhinal cortex (MEC) biases reward-predictive behaviors and supports memory-guided navigation.

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairment

This study links tau pathology in the medial entorhinal cortex to spatial memory impairment by showing dysregulated neural activity and sex-specific resilience in PS19 tauopathy mice.

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

The paper shows that slow hippocampus-to-entorhinal plasticity underlies gradual grid cell map formation and fragmentation in novel environments through longitudinal imaging and modeling.

Structural and Functional Insights into GGCX-FIX Interaction: Implications for Vitamin K-Dependent Bleeding Disorders

This study identifies key functional regions of GGCX and their interactions with FIX using AlphaFold 3 and simulations, revealing residues critical for carboxylation and vitamin K epoxidation.

Genome-wide identification of silencers in human cells

The paper identifies silencer regions in three human cell lines using MPRAs, finding 739,434, 643,484, and 491,952 silencer regions with inhibitory activity and enriched inhibitory motifs.

Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality

The paper identifies a new cell class in the mouse medial entorhinal cortex that encodes visual cue information to correct path integration errors during navigation.