Author

L. A. Bindoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Tzoulis· 2 shared A. Chen· 1 shared C. Lundberg· 1 shared G. J. Sullivan· 1 shared G. S. Nido· 1 shared G. Sullivan· 1 shared I. K. N. Pettersen· 1 shared K. X. Liang· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

C. Tzoulis

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Author profile →

2 papers

Recent·Most cited

Hallmark molecular and pathological features of POLG disease are recapitulated in cerebral organoids

K. X. Liang, A. Chen, T. Yangzom, Y. Hong, C. Lundberg, G. J. Sullivan, C. Tzoulis, L. A. Bindoff

This paper develops a cerebral organoid model of POLG disease that recapitulates its molecular and pathological features, including mtDNA depletion and neuronal loss, and shows metformin can alleviate some abnormalities.

bioRxiv · Sep 16, 2023Cell Biology

Distinct mitochondrial remodeling during early cardiomyocyte development in a human-based stem cell model

S. Mostafavi, N. Balafkan, I. K. N. Pettersen, G. S. Nido, R. Siller, C. Tzoulis, G. Sullivan, L. A. Bindoff

This study investigates mitochondrial remodeling during human stem cell differentiation to cardiomyocytes, finding that mitochondrial content decreases despite increased activity and respiration.

bioRxiv · Jul 7, 2021 · PreprintCell Biology