Cell BiologybioRxiv
Hallmark molecular and pathological features of POLG disease are recapitulated in cerebral organoids
K. X. Liang, A. Chen, T. Yangzom…·L. A. Bindoff
This paper develops a cerebral organoid model of POLG disease that recapitulates its molecular and pathological features, including mtDNA depletion and neuronal loss, and shows metformin can alleviate some abnormalities.
DOI 10.1002/advs.202307136