Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases
C. Durfee, N. A. Temiz, R. Levin-Klein, P. Argyris, L. Alsoe, S. Carracedo, A. Alonso, J. Proehl, A. Holzhauer, Z. Seeman, Y.-H. T. Lin, R. I. Vogel, R. Sotillo, H. Nilsen, R. Harris
This study shows that human APOBEC3B causes tumor heterogeneity and metastases in mice, with increased C-to-T mutations and structural variations.
bioRxiv · Feb 24, 2023 · PreprintCancer Biology