P. Argyris

Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases

This study shows that human APOBEC3B causes tumor heterogeneity and metastases in mice, with increased C-to-T mutations and structural variations.

Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

This study quantifies the mutagenic activities of APOBEC3A and APOBEC3B in a human cell line and compares their mutation signatures to breast cancer genomes, showing both enzymes contribute to the mutation landscape.

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

This paper describes the generation and characterization of a rabbit monoclonal antibody against APOBEC3B, showing its potential as a research tool and clinical biomarker for cancer.