R. Sotillo

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Chronic deregulation of the spindle assembly checkpoint triggers myelosuppression and gastrointestinal atrophy

The paper investigates the effects of chronic SAC activation in mice, finding it causes bone marrow aplasia and intestinal atrophy, with BIM playing a critical role in gastrointestinal cell death.

A signalling rheostat controls chromosome segregation fidelity during early lineage specification and neurogenesis by modulating DNA replication stress

The paper identifies a signalling rheostat involving WNT, BMP, and FGF that modulates DNA replication stress and chromosome segregation fidelity during lineage specification and neurogenesis.

Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases

This study shows that human APOBEC3B causes tumor heterogeneity and metastases in mice, with increased C-to-T mutations and structural variations.

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

This study shows that Plk1-induced chronic chromosome instability in breast cancer leads to immune suppression through RELB signaling and PD-L1 upregulation.

Diverse routes of Club cell evolution in lung adenocarcinoma

This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.

Dual airway and alveolar contributions to adult lung homeostasis and carcinogenesis

This study identifies airway contributions to alveolar maintenance and lung adenocarcinoma development through mouse models and transcriptomic analysis.

Plk1 overexpression suppresses tumor development by inducing chromosomal instability

This study shows that Plk1 overexpression suppresses tumor development by causing chromosomal instability and cytokinesis defects, despite its role as an oncogene.