Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis
C. Borga, G. Park, C. Foster, J. Burroughs-Garcia, M. Marchesin, S. T. Ahmed, S. Bresolin, L. Batchelor, T. Scordino, R. R. Miles, G. te Kronnie, J. L. Regens, J. K. Frazer
This paper establishes the first zebrafish pre-B ALL model driven by human MYC, which also develops T-ALL, revealing differences in leukemogenesis and offering therapeutic insights.
bioRxiv · Mar 13, 2018Cancer Biology