G. Park

Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method

This paper introduces a novel biopsy method to study zebrafish epidermal lymphocytes, revealing diverse cell types and their gene expression profiles.

Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets

The paper shows that the disordered C-terminal domain of RNAPII confines its diffusion to a subnuclear region, enhancing target search efficiency in yeast.

Topology of gene regulatory compartments relative to the nuclear matrix

The paper visualizes the nuclear matrix and intranuclear compartments using super-resolution microscopy, revealing their layered distribution and role in transcriptional regulation.

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

This study shows ATP binding enables SWR1 chromatin remodeler to diffuse along DNA, facilitating efficient target search by sliding over DNA until encountering roadblocks.

Coordinated DNA and Histone Dynamics Drive Accurate Histone H2A.Z Exchange

The paper uses single-molecule FRET to show SWR1 unwraps DNA and exchanges H2A-H2B for H2A.Z-H2B with timed precision.

SMURF2 phosphorylation at Thr249 modifies the stemness and tumorigenicity of glioma stem cells by regulating TGF-β receptor stability

This study shows that SMURF2 phosphorylation at Thr249 regulates GSC stemness and tumorigenicity by affecting TGF-β receptor stability.

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation

This study identifies drug-induced secretome fucosylation as a mechanism of resistance to targeted therapies across multiple cancers.

Rapid, but limited, zooplankton adaptation to simultaneous warming and acidification

The paper shows rapid but limited adaptation in copepod populations to combined ocean warming and acidification over 25 generations.

Somatic Mutations in Clonally Expanded T-lymphocytes in Patients with Chronic Graft-Versus-Host Disease

This study identifies somatic mutations in clonally expanded T-cells in chronic GvHD patients, showing they drive persistent activation and resistance to mTOR inhibitors.

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis

This paper establishes the first zebrafish pre-B ALL model driven by human MYC, which also develops T-ALL, revealing differences in leukemogenesis and offering therapeutic insights.

Visualization And Label-Free Quantification Of Microfluidic Mixing Using Quantitative Phase Imaging

The paper visualizes and quantifies microfluidic mixing using quantitative phase imaging without exogenous labels, validated against Fick's law calculations.