The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling
V. Chan, C. Camardi, K. Zhang, L. Orofiamma, K. E. Anderson, J. Hoque, L. Bone, Y. Awadeh, D. K. C. Lee, N. J. Fu, J. T. S. Chow, L. Salmena, L. R. Stephens, P. T. Hawkins, C. N. Antonescu, R. J. Botelho
This study shows that LCLAT1 is required for EGF-mediated PtdIns(3,4,5)P3 generation and Akt signaling in cancer and retinal cells.
bioRxiv · Jan 26, 2023Cell Biology