Author

V. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 3 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

A. A. Rao· 4 shared J. Tsui· 4 shared M. F. Krummel· 4 shared A. J. Combes· 3 shared A. Boissonnas· 2 shared A. Shen· 2 shared B. Samad· 2 shared D. J. Erle· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

A. A. Rao

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners

A. L. Robertson, L. Yue, A. Choudhuri, D. Fernandez-Perez, A. Maya, C. Kubaczka, S. J. Wattrus, K. Drake, J. Mandelbaum, S. Avagyan, S. Yang, R. Bhattacharya, R. J. Freeman, V. Chan, M. C. Blair, , L. I. Zon

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

bioRxiv · Jun 7, 2024 · PreprintCell Biology

The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling

V. Chan, C. Camardi, K. Zhang, L. Orofiamma, K. E. Anderson, J. Hoque, L. Bone, Y. Awadeh, D. K. C. Lee, N. J. Fu, J. T. S. Chow, L. Salmena, L. R. Stephens, P. T. Hawkins, C. N. Antonescu, R. J. Botelho

This study shows that LCLAT1 is required for EGF-mediated PtdIns(3,4,5)P3 generation and Akt signaling in cancer and retinal cells.

bioRxiv · Jan 26, 2023Cell Biology

Transplantation-based screen uncovers inducers of muscle progenitor cell engraftment across vertebrate species

S. Tavakoli, V. Garcia, E. Gahwiler, I. Adatto, A. Rangan, K. Messemer, S. Ashrafi Kakhki, S. Yang, V. Chan, M. Manning, H. Fotowat, A. Wagers, L. Zon

The paper identifies two lipids that enhance muscle progenitor cell engraftment across zebrafish and mice by activating intracellular calcium flux.

bioRxiv · Jan 13, 2023 · PreprintCell Biology

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

A. M. Mujal, A. J. Combes, A. A. Rao, M. Binnewies, B. Samad, J. Tsui, A. Boissonnas, J. L. Pollack, R. J. Arguello, M. K. Ruhland, K. C. Barry, V. Chan, M. F. Krummel

This study characterizes monocyte-to-macrophage differentiation in kidney cancer using scRNA-seq, linking immune phenotypes to T cell function and patient outcomes.

bioRxiv · Jul 7, 2021Immunology

Multiomic Characterization of Stage I Lung Adenocarcinoma Reveals Distinct Genetic and Immunologic Features of Recurrent Disease

J. R. Kratz, J. Z. Li, J. Tsui, J. C. Lee, V. W. Ding, A. A. Rao, M. J. Mann, V. Chan, A. R. Combes, M. F. Krummel, D. M. Jablons

This study identifies distinct genetic and immunologic features of recurrent stage I lung adenocarcinoma using multiomic profiling and single-cell RNA-seq.

bioRxiv · May 20, 2021 · PreprintCancer Biology

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

A. J. Combes, B. Samad, J. Tsui, N. W. Chew, P. Yan, G. C. Reeder, D. Kushnoor, A. Shen, B. Davidson, A. J. Barczac, M. Adkisson, A. Edwards, M. Naser, K. C. Barry, T. Courau, , M. F. Krummel

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

bioRxiv · Apr 26, 2021 · PreprintImmunology

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

A. J. Combes, T. Courau, N. F. Kuhn, K. H. Hu, A. Ray, W. S. Chen, S. J. Clearly, N. W. Chew, D. Kushnoor, G. C. Reeder, A. Shen, J. Tsui, K. J. Hiam-Galvez, P. Munoz-Sandoval, W. S. Zhu, , M. F. Krummel

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

bioRxiv · Oct 28, 2020Immunology

Field efficacy of guppies and pyriproxyfen (Sumilarv(R) 2MR) combined with community engagement on dengue vectors in Cambodia: a randomized controlled trial

J. C. Hustedt, D. Doum, V. Keo, S. Ly, B. Sam, V. Chan, N. Alexander, J. Bradley, M. Liverani, D. B. Prasetyo, A. Rachmat, M. Shafique, S. Lopes, L. Rithea, J. Hii

This study evaluates the effectiveness of guppies and pyriproxyfen combined with community engagement in reducing dengue vector populations in Cambodia, finding significant reductions in adult female Aedes density.

bioRxiv · May 15, 2020Ecology