R. J. Botelho

This study shows Salmonella modulates TFEB in macrophages depending on its growth phase and infection time, with stationary-phase Salmonella delaying TFEB nuclear mobilization while late-log Salmonella allows TFEB activation.

This study shows that LCLAT1 is required for EGF-mediated PtdIns(3,4,5)P3 generation and Akt signaling in cancer and retinal cells.

This paper demonstrates that silver nanoparticles enhance lysosome fluorescence, enabling live-cell imaging with reduced phototoxicity and preserved dynamics.

This study investigates how AMPK mediates cellular recovery from metabolic stress caused by ultrasound microbubble treatment in breast cancer cells.

This study identifies a novel crosstalk between Inpp4b and PIKfyve that regulates lysosome membrane phosphoinositide composition and homeostasis by restricting VPS34-dependent PtdIns(3)P production.

This study shows that reactive oxygen species (ROS) prevent lysosome coalescence during PIKfyve inhibition through distinct mechanisms depending on the ROS type.

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

This study shows that phagosome resolution through clathrin-dependent fragmentation regenerates lysosomes and maintains macrophage degradative capacity after multiple rounds of phagocytosis.

This study shows that PIKfyve inhibition causes lysosome coalescence, leading to fewer enlarged lysosomes, and that TFEB-mediated biosynthesis does not drive this swelling.