BiochemistrybioRxiv
Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa
E. M. Martinez, R. Toelle, J. Donauer…·J. Dengjel
The paper shows that in RDEB, increased Cbl E3 ligase activity due to TGFβ signaling impairs PDGFR signaling, leading to reduced wound healing.
DOI 10.1016/j.matbio.2021.10.004