LXR-inducible host E3 ligase IDOL targets a human cytomegalovirus reactivation determinant
L. Mlera, D. K. Collins-McMillen, S. Zeltzer, J. Buehler, M. Moy, K. Zarrella, K. Caviness, L. Cicchini, D. J. Tafoya, F. Goodrum
This paper identifies IDOL as an E3 ligase that targets HCMV UL136p33 for degradation, linking its instability to latency establishment and reactivation.
bioRxiv · Nov 15, 2022 · PreprintMicrobiology