Author

F. Goodrum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. P. Kamil· 4 shared D. K. Collins-McMillen· 3 shared J. Buehler· 3 shared K. Zarrella· 3 shared S. Zeltzer· 3 shared A. J. Domma· 2 shared D. Collins-McMillen· 2 shared J. A. Nelson· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

J. P. Kamil

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9 papers

Recent·Most cited

Viral and host network analysis of the human cytomegalovirus transcriptome in latency.

D. K. Collins-McMillen, D. De Oliveira Pessoa, K. Zarrella, C. J. Parkins, M. Daily, N. K. Moorman, J. P. Kamil, P. Caposio, M. Padi, F. Goodrum

The paper analyzes the transcriptional network of HCMV in latency by comparing gene expression with and without UL135 and UL138, revealing their roles in viral gene regulation and hematopoietic differentiation.

bioRxiv · May 21, 2024Microbiology

Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins

A. J. Domma, F. Goodrum, N. J. Moorman, J. P. Kamil

This study shows that human cytomegalovirus (HCMV) inactivates AKT by using UL38 to degrade IRS1, which is necessary for AKT activation during infection.

bioRxiv · Apr 17, 2023Microbiology

Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection

K. Zarrella, P. Longmire, S. Zeltzer, D. Collins-McMillen, M. Hancock, J. Buehler, J. M. Reitsma, S. S. Terhune, J. A. Nelson, F. Goodrum

This study identifies the UL138-UAF1-USP1 interaction in HCMV that activates STAT1 to regulate latency establishment through innate immune signaling.

bioRxiv · Feb 7, 2023Microbiology

UL135 and UL136 Epistasis Controls Reactivation of Human Cytomegalovirus

M. A. Moy, D. K. Collins-McMillen, L. Crawford, C. Parkins, S. Zeltzer, K. Caviness, P. Caposio, F. Goodrum

This study shows that stabilizing UL136p33 compensates for the loss of UL135 in HCMV reactivation from latency in hematopoietic cells.

bioRxiv · Jan 24, 2023 · PreprintMicrobiology

LXR-inducible host E3 ligase IDOL targets a human cytomegalovirus reactivation determinant

L. Mlera, D. K. Collins-McMillen, S. Zeltzer, J. Buehler, M. Moy, K. Zarrella, K. Caviness, L. Cicchini, D. J. Tafoya, F. Goodrum

This paper identifies IDOL as an E3 ligase that targets HCMV UL136p33 for degradation, linking its instability to latency establishment and reactivation.

bioRxiv · Nov 15, 2022 · PreprintMicrobiology

The AKT Forkhead box O transcription factor axis regulates human cytomegalovirus replication

H. Zhang, A. J. Domma, F. Goodrum, N. Moorman, J. P. Kamil

This study shows that HCMV inactivates AKT to promote FOXO3a nuclear localization, which is required for efficient viral replication.

bioRxiv · Apr 14, 2022Microbiology

Cell type-specific biogenesis of novel vesicles containing viral products in human 1cytomegalovirus infection

S. Momtaz, B. Molina, L. Mlera, F. Goodrum, J. M. Wilson

This study identifies cell-type specific biogenesis of virus-containing vesicles in HCMV-infected fibroblasts and endothelial cells using fluorescently labeled virus and microscopy.

bioRxiv · Dec 10, 2020Microbiology

FOXO Transcription Factors Activate Alternative Major Immediate Early Promoters to Induce Human Cytomegalovirus Reactivation

A. E. Hale, D. Collins-McMillen, E. M. Lenarcic, J. P. Kamil, F. Goodrum, N. J. Moorman

This study identifies FOXO transcription factors as critical for activating alternative MIE promoters during HCMV reactivation from latency in hematopoietic progenitor cells.

Proceedings of the National Academy of Sciences · Jul 21, 2020Peer-reviewedMicrobiology

HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

I. A. Mikell, L. B. Crawford, M. H. Hancock, J. Mitchell, J. Buehler, F. Goodrum, J. A. Nelson

This study shows HCMV miR-US22 down-regulates EGR-1, reducing CD34+ HPC proliferation and colony formation, and preventing viral reactivation.

bioRxiv · May 21, 2019Microbiology