J. Buehler

Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection

This study identifies the UL138-UAF1-USP1 interaction in HCMV that activates STAT1 to regulate latency establishment through innate immune signaling.

LXR-inducible host E3 ligase IDOL targets a human cytomegalovirus reactivation determinant

This paper identifies IDOL as an E3 ligase that targets HCMV UL136p33 for degradation, linking its instability to latency establishment and reactivation.

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

RNA-binding protein Orb2 causes microcephaly and supports centrosome asymmetry in Drosophila neural stem cells

This study shows Orb2 supports centrosome asymmetry in Drosophila NSCs, leading to microcephaly when lost, and identifies a conserved role for CPEB proteins in centrosome regulation.

Development and validation of IMMUNO-COV: a high-throughput clinical assay for detecting antibodies that neutralize SARS-CoV-2

The paper develops and validates IMMUNO-COV, a high-throughput assay that accurately quantifies SARS-CoV-2-neutralizing antibodies in human sera.

HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

This study shows HCMV miR-US22 down-regulates EGR-1, reducing CD34+ HPC proliferation and colony formation, and preventing viral reactivation.

Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency

This study identifies alternative promoters that drive HCMV reactivation from latency, challenging the previous understanding that the MIEP is the primary driver.