Novel organelle anion channels formed by chromogranin B drive normal granule maturation in endocrine cells
G. Yadav, H. Zheng, Q. Yang, L. Douma, M. Annamalai, L. Bloom, C. Mathews, Q.-X. Jiang
This study identifies CHGB as a novel anion channel essential for secretory granule maturation in endocrine cells, showing its role in granule acidification and function in both intracellular and extracellular contexts.
bioRxiv · Apr 17, 2018Cell Biology