H. Zheng

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

The paper identifies conserved antiviral pathways across macaques and humans using transcriptomic data from viral infections, showing shared and virus-specific responses that inform pandemic preparedness.

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

This study determines the crystal structure of Legionella collagen-like protein and reveals its unique binding mechanism for sulphated glycosaminoglycans.

The paper identifies molecular predictors of domoic acid production during a harmful algal bloom and links iron and silica co-limitation to bloom dynamics and toxicity.

This study combines high-resolution physical and multi-omic sampling to identify DA biosynthetic gene expression in frontal zones of Monterey Bay during declining upwelling.

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

This paper introduces a FLIM-based method to quantitatively analyze lysosomal pH heterogeneity in mammalian cells and C. elegans, revealing pH differences and dynamics without transgenic reporters.

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

This study identifies Tafazzin's role in tamoxifen resistance by regulating phospholipid composition in ER+ breast cancer cells, showing that TAZ depletion promotes resistance via an LPC-LPA axis.

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.

This study identifies sex-specific circulating markers of plaque instability in men and women with severe carotid atherosclerosis, showing differences in immune and lipid profiles between sexes.

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

This study establishes the Pig Virome Database (PVD) by mining global metagenomic data, revealing extensive viral diversity and functional potential in the pig gut.

This study shows that inhibiting host N-myristoylation reduces SARS-CoV-2 infectivity by impairing viral envelope protein maturation and causing Golgi-bypassing egress.

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

The paper identifies CPK32 as a kinase that phosphorylates CESA3, affecting CSC motility and stability, thereby regulating cellulose biosynthesis.

This study develops an extracellular vesicle-based test to detect early-stage high-grade serous ovarian cancer with high sensitivity and specificity using markers identified from murine models and validated in a human pilot study.

The paper shows engineered symbiotic bacteria can inhibit microsporidia infection in honeybees by delivering RNAi targeting the parasite's redox system.

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

The paper analyzes NRE sequences in RLKs and RLCKs from 528 plants to uncover structural-functional relationships and phosphorylation motifs, revealing their role in kinase regulation.

The paper introduces a deep learning framework that improves classification of marine images by using scene classification to enhance accuracy in diverse underwater environments.