Norovirus replication in human intestinal epithelial cells is restricted by the interferon-induced JAK/STAT signalling pathway and RNA Polymerase II mediated transcriptional responses.
M. T. Hosmillo, Y. Chaudhry, K. Nayak, F. Sorgeloos, B.-K. Koo, A. Merenda, R. Lillestol, L. Drumright, M. Zilbauer, I. G. Goodfellow
This study shows that HuNoV replication in intestinal epithelial cells is restricted by IFN-induced transcriptional responses and that inhibiting these responses enhances viral replication.
bioRxiv · Aug 10, 2019 · PreprintMicrobiology