Author

F. Sorgeloos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

I. G. Goodfellow· 3 shared A. S. Jahun· 2 shared I. Goodfellow· 2 shared M. Hosmillo· 2 shared A. Merenda· 1 shared B. Lizcano-Perret· 1 shared B. S. Hall· 1 shared B.-K. Koo· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersMicrobiology

I. G. Goodfellow

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Author profile →

6 papers

Recent·Most cited

Porcine sapovirus protease controls the innate immune response and targets TBK1

I. Georgana, M. Hosmillo, A. S. Jahun, E. Emmott, F. Sorgeloos, K.-O. Cho, I. G. Goodfellow

This study shows that the porcine sapovirus protease NS6 inhibits type I IFN production by targeting TBK1, revealing a mechanism for immune evasion and establishing a new cell line model for PSaV research.

bioRxiv · Dec 21, 2023Microbiology

Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic

B. Lizcano-Perret, C. Lardinois, F. Wavreil, P. Hauchamps, G. Herinckx, F. Sorgeloos, D. Vertommen, L. Gatto, T. Michiels

The paper shows Cardiovirus leader protein redirects RSK kinases to phosphorylate nucleoporins, disrupting nucleocytoplasmic transport.

bioRxiv · Jun 16, 2022Microbiology

Murine Norovirus infection results in anti-inflammatory response downstream of amino acids depletion in macrophages

M. Brocard, J. Lu, B. S. Hall, K. Borah, C. Moller-Levet, F. Sorgeloos, D. Beste, I. G. Goodfellow, N. Locker

This study shows that murine norovirus induces metabolic stress in macrophages, leading to anti-inflammatory responses through amino acid depletion and GCN2/ATF2 signaling, rather than a typical innate immune response.

bioRxiv · Apr 22, 2021Microbiology

Norovirus replication in human intestinal epithelial cells is restricted by the interferon-induced JAK/STAT signalling pathway and RNA Polymerase II mediated transcriptional responses.

M. T. Hosmillo, Y. Chaudhry, K. Nayak, F. Sorgeloos, B.-K. Koo, A. Merenda, R. Lillestol, L. Drumright, M. Zilbauer, I. G. Goodfellow

This study shows that HuNoV replication in intestinal epithelial cells is restricted by IFN-induced transcriptional responses and that inhibiting these responses enhances viral replication.

bioRxiv · Aug 10, 2019 · PreprintMicrobiology

Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection

C. Borg, A. S. Jahun, L. Thorne, F. Sorgeloos, D. Bailey, I. Goodfellow

This study shows that VF1 in MNV contributes to viral fitness during persistent infection but is not essential for persistence.

bioRxiv · May 23, 2019Microbiology

Epigenetic suppression of interferon lambda receptor expression leads to enhanced HuNoV replication in vitro

S. E. Arthur, F. Sorgeloos, M. Hosmillo, I. Goodfellow

This study identifies epigenetic suppression of IFNLR1 as a mechanism enhancing HuNoV replication in vitro by reducing antiviral interferon lambda signaling.

bioRxiv · Jan 21, 2019Microbiology