Author

L. Fets

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Anastasiou· 3 shared J. Kleinjung· 2 shared M. Silva dos Santos· 2 shared P. M. Nunes· 2 shared A. Asuaje· 1 shared A. Jain· 1 shared A. P. Snijders· 1 shared A. Theisen· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

D. Anastasiou

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

F. Grimm, A. Asuaje, A. Jain, M. Silva dos Santos, J. Kleinjung, P. M. Nunes, S. Gehrig, L. Fets, J. MacRae, D. Anastasiou

This study identifies GOT1 as a key factor in priming cells for hypoxic adaptation by enhancing glycolysis and HIF1α stabilization before full HIF1 activation.

bioRxiv · Sep 6, 2023 · PreprintCancer Biology

Novel MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

L. Fets, N. Bevan, P. M. Nunes, S. Campos, M. Silva dos Santos, E. B. Sherriff, J. I. MacRae, D. House, D. Anastasiou

The paper designs and characterizes MOG analogues to study MCT2 pharmacophore, KG biology, and cellular effects of NOG, showing compounds that inhibit PHDs without cytotoxicity.

bioRxiv · Mar 15, 2021Biochemistry

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

J. A. Macpherson, A. Theisen, L. Masino, L. Fets, P. C. Driscoll, V. Encheva, A. P. Snijders, S. R. Martin, J. Kleinjung, P. E. Barran, F. Fraternali, D. Anastasiou

The paper investigates how PKM2 activity is regulated by simultaneous binding of activating and inhibiting ligands, revealing a mechanism for integrating allosteric inputs.

bioRxiv · Jul 26, 2018Biochemistry