Heterogeneous transcriptome response to DNA damage at single cell resolution.
S. R. Park, S. Namkoong, Z. Z. Zhang, L. Friesen, Y.-C. Chen, E. Yoon, C. H. Kim, H. Kwak, H. M. Kang, J. H. Lee
The paper shows that DNA damage induces heterogeneous transcriptome responses in cancer cells, with distinct transcriptional programs dictating cell fate outcomes such as checkpoint, apoptosis, or chemoresistance.
bioRxiv · Aug 15, 2019Cell Biology