H. M. Kang

Seq-Scope provides submicrometer-resolution spatial transcriptomics for single-cell and subcellular analysis by using barcoded clusters on an Illumina platform.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

This study uses single-cell RNA-sequencing to analyze how hepatocytes respond to high-fat diet and NAFLD, revealing heterogeneous transcriptomic changes across liver zones.

The paper shows that DNA damage induces heterogeneous transcriptome responses in cancer cells, with distinct transcriptional programs dictating cell fate outcomes such as checkpoint, apoptosis, or chemoresistance.