E. Yoon

A compact, ultrahigh-density headstage with high-fidelity hybrid integration for large-scale deep-brain opto-electrophysiology

This paper introduces a high-channel-count optogenetic system for deep-brain studies, achieving high spatial resolution in recording and stimulation with unprecedented channel density.

Caf1 regulates Ash1 histone methyltransferase activity via sensing unmodified histone H3.

The paper investigates how Caf1 regulates Ash1's histone methyltransferase activity by sensing unmodified histone H3K4, revealing a regulatory crosstalk between H3K4 and H3K36 methylation.

flexLiTE: flexible micro-LED integrated optoelectrodes for long-term chronic deep-brain studies

flexLiTE enables long-term chronic opto-electrophysiology in mice by integrating micro-LEDs and recording electrodes for neuronal recording and modulation.

Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity

The paper reports the cryo-EM structure of human SSTR2 bound to somatostatin, revealing ligand binding specificity and interactions with Gi proteins.

HectoSTAR microLED optoelectrodes for large-scale, high-precision in invo opto-electrophysiology

The paper introduces HectoSTAR microLED optoelectrodes for large-scale in vivo opto-electrophysiology, enabling high-precision extracellular recording and optical modulation of over 100 neuronal targets.

High-density Neural Recordings from Feline Sacral Dorsal Root Ganglia with Thin-film Array

This study demonstrates high-density neural recordings from feline sacral dorsal root ganglia using a flexible microelectrode array, achieving single-unit activity detection and tracking during sensory stimulation.

NFATC4 Promotes Quiescence and Chemotherapy Resistance in Ovarian Cancer

This study identifies NFATC4 as a regulator of quiescence and chemotherapy resistance in ovarian cancer, showing its role in promoting a non-proliferative state and poor prognosis.

Heterogeneous transcriptome response to DNA damage at single cell resolution.

The paper shows that DNA damage induces heterogeneous transcriptome responses in cancer cells, with distinct transcriptional programs dictating cell fate outcomes such as checkpoint, apoptosis, or chemoresistance.

Artifact-free, high-temporal-resolution in vivo opto-electrophysiology with microLED optoelectrodes

This paper introduces miniSTAR microLED optoelectrodes that eliminate stimulation artifacts in opto-electrophysiology, enabling high-temporal-resolution in vivo recordings.

Ultra-compliant carbon nanotube stretchable direct bladder interface

This paper develops a stretchable bladder interface using carbon nanotubes and Ecoflex, demonstrating its sensing and stimulation capabilities in vivo.

Mechanobiological Conditioning of Mesenchymal Stem Cells Enhances Therapeutic Angiogenesis by Inducing a Hybrid Pericyte-Endothelial Phenotype

This study shows that combining mechanical strain and kinase inhibitors enhances mesenchymal stem cells to express pericyte and endothelial markers, improving their angiogenic capabilities.

High Throughput Mechanobiological Screens Enable Mechanical Priming of Pluripotency in Mouse Fibroblasts

The paper identifies small molecules that synergize with mechanical loading to prime pluripotency in mouse fibroblasts using high throughput mechanobiological screens.

Novel diamond shuttle to deliver flexible bioelectronics with reduced tissue compression

This paper introduces a diamond shuttle for delivering flexible bioelectronics with reduced tissue compression, showing improved performance in rat and feline models.