Discovery of small molecule inhibitors of the PTK7/β-catenin interaction targeting the Wnt signaling pathway in colorectal cancer
L. Ganier, S. Betzi, C. Derviaux, P. Roche, C. Muller, L. Hoffer, X. Morelli, J.-P. Borg
This study identifies small molecule inhibitors of the PTK7/β-catenin interaction in colorectal cancer, showing anti-proliferative effects in cells with Wnt pathway mutations.
bioRxiv · Oct 15, 2021 · PreprintPharmacology & Toxicology