Author

P. Roche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1

Frequent Co-Authors

C. Derviaux· 2 shared L. Hoffer· 2 shared S. Betzi· 2 shared X. Morelli· 2 shared A. Barneoud· 1 shared A. Guiseppi· 1 shared A. Moine· 1 shared A. Restouin· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

C. Derviaux

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation

K. Carrasco, C. Montersino, C. Derviaux, M. Saez-Ayala, L. Hoffer, A. Restouin, R. Castellano, J. Casassa, P. Roche, E. Pasquier, S. Combes, X. Morelli, Y. Collette, S. Betzi

The paper identifies CRCM5484, a BDII-selective BET inhibitor, and shows its differential modulation of anti-leukemic drug activity in combination with other compounds.

bioRxiv · Dec 13, 2021Cancer Biology

Discovery of small molecule inhibitors of the PTK7/β-catenin interaction targeting the Wnt signaling pathway in colorectal cancer

L. Ganier, S. Betzi, C. Derviaux, P. Roche, C. Muller, L. Hoffer, X. Morelli, J.-P. Borg

This study identifies small molecule inhibitors of the PTK7/β-catenin interaction in colorectal cancer, showing anti-proliferative effects in cells with Wnt pathway mutations.

bioRxiv · Oct 15, 2021 · PreprintPharmacology & Toxicology

Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics

J. Serrano-Lopez, S. Hegde, S. Kumar, J. Serrano, J. Fang, A. Wellendorf, P. Roche, Y. Rangel, L. J. Carrington, H. Geiger, L. Grimes, S. Luther, I. Maillard, J. Sanchez-Garcia, D. Starczynowski, J. Cancelas

The paper shows that systemic inflammation triggers rapid migration of specific myeloid progenitors from bone marrow to lymphatics via Ccl19/Ccr7, promoting anti-inflammatory responses and replenishment of lymph node dendritic cells.

bioRxiv · Jan 20, 2021 · PreprintImmunology

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

A. Guiseppi, J.-J. Vicente, J. Herrou, A. Barneoud, A. Moine, L. Espinosa, M.-J. Basse, V. Molle, T. Mignot, P. Roche, E. Mauriello

The paper identifies FrzB, a divergent CheW in M. xanthus, which lacks the CheA-interacting region and functions upstream of FrzCD to enable distributed chemosensory arrays on the nucleoid, conferring plasticity to chemosensory systems.

bioRxiv · Oct 25, 2019Microbiology

Receptor Mediated Delivery of Cas9-Nanobody Induces Cisplatin Synthetic Dose Sensitivity

P. Roche, H. Gytz Olesen, F. Hussain, Y. Liang, N. Stub Laursen, K. R. Andersen, B. Nagar, U. D. Akavia

This study demonstrates receptor-mediated delivery of Cas9-Nanobody to A549 cells, enhancing cisplatin sensitivity through synthetic dose lethality.

bioRxiv · Aug 9, 2018 · PreprintBiochemistry