J.-P. Borg

Downregulation of stromal syntenin sustains AML development

This study shows that reduced stromal syntenin in bone marrow stromal cells promotes AML aggressiveness by enhancing AML cell survival and protein synthesis through endoglin upregulation.

Discovery of small molecule inhibitors of the PTK7/β-catenin interaction targeting the Wnt signaling pathway in colorectal cancer

This study identifies small molecule inhibitors of the PTK7/β-catenin interaction in colorectal cancer, showing anti-proliferative effects in cells with Wnt pathway mutations.

The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins

This study identifies MINK1 as a kinase that phosphorylates LL5β, a component of the PRICKLE1 complex, promoting cell migration in triple-negative breast cancer and associating with poor metastasis-free survival.

Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule

This study identifies the structural basis of Tax-1 interaction with syntenin-1 and demonstrates small-molecule inhibition of this interaction to target HTLV-1.

The unique Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins

This study shows that Brucella effectors NyxA and NyxB target SENP3 to alter nucleolar protein localization, promoting bacterial replication.

A syntenin-deficient microenvironment educates AML for aggressiveness

This study shows that syntenin-deficiency in the bone marrow microenvironment promotes AML aggressiveness by enhancing cell survival through autophagy and protein synthesis.

PLD2-phosphatidic acid recruit ESCRT-I to late endosomes for exosome biogenesis.

The paper shows PLD2 and phosphatidic acid recruit ESCRT-I to late endosomes, facilitating exosome biogenesis through MVB12B interactions.

A novel Golgi-associated Vangl2 translational variant required for PCP regulation in vertebrates

The paper identifies a novel Vangl2 isoform, Vangl2-Long, which is localized to the Golgi apparatus and plays a critical role in PCP regulation in vertebrates.

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

This study develops a mouse model of TNBC that recapitulates human tumor heterogeneity and identifies a synergistic combination of WEE1 and BCL-XL inhibition as a potential treatment.

CRB2 controls primary ciliogenesis in association with PAR6α, HOOK2 and RAB8A

This study shows CRB2 is required for primary ciliogenesis by forming a complex with HOOK2 and PAR6 and interacting with RAB8A to regulate membrane transport for ciliary vesicle formation.

Brucella effector hijacks endoplasmic reticulum quality control machinery to prevent premature egress

This study identifies BspL, a Brucella effector that modulates ERQC to control autophagic vacuole formation and prevent bacterial premature egress.

ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer

The paper identifies PRICKLE1 and ECT2 as poor-prognosis markers in triple-negative breast cancer by showing their interaction and role in RAC1 signaling.