Metalloprotease Gp63 targeting novel glycoside exhibits potential antileishmanial activity
A. Chakrabarty, C. Narayana, N. Joshi, S. Garg, L. Garg, R. Sagar, S. Pati, s. singh
This study identifies a glycoside derivative, Gly 2, with potent antileishmanial activity against Leishmania donovani, targeting the metalloprotease Gp63 and showing efficacy against both visceral leishmaniasis and post-kala-azar dermal leishmaniasis.
bioRxiv · Sep 11, 2020Pharmacology & Toxicology