S. Pati

G6PD deficiency mediated impairment of iNOS and lysosomal acidification affecting phagocytotic clearance in microglia in response to SARS-CoV-2

This study shows that G6PD deficiency in microglia impairs iNOS-mediated NO production and lysosomal acidification, leading to reduced phagocytosis of SARS-CoV-2 and increased COVID-19 severity.

Genotypic and phenotypic diversity of the multidrug-resistant Mycobacterium tuberculosis strains from eastern India

This study sequenced Mtb genomes from eastern India to analyze genotypic and phenotypic diversity, revealing high prevalence of MDR lineage-2 strains in NE and lineage-1/3 in Odisha, with local transmission clusters and enrichment of short INDELs in MDR samples.

Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutated receptor binding domain with ACE2 receptor

The study analyzes SARS-CoV-2 isolates from India, finding a mutation in the RBD that increases binding affinity to human ACE2, suggesting potential for higher infectivity and cross-species transmission.

Metalloprotease Gp63 targeting novel glycoside exhibits potential antileishmanial activity

This study identifies a glycoside derivative, Gly 2, with potent antileishmanial activity against Leishmania donovani, targeting the metalloprotease Gp63 and showing efficacy against both visceral leishmaniasis and post-kala-azar dermal leishmaniasis.

An equivalence of prokaryotic pore forming proteins of Plasmodium triggers cellular dysfunction responsible for malaria pathogenesis

This study shows that Plasmodium falciparum pore-forming proteins (PLPs) induce barrier cell dysfunction through necrotic cell death, contributing to severe malaria pathogenesis.

Horseshoe crab genomes reveal the evolutionary fates of genes and microRNAs after three rounds (3R) of whole genome duplication

Role of RBC membrane protein palmitoylation in regulation of molecular topology and susceptibility to Plasmodium falciparum invasion

The paper investigates how palmitoylation affects RBC membrane proteins and their role in Plasmodium falciparum invasion, finding that palmitoylation regulates receptor expression and susceptibility.

Interaction of 14-3-3I and CDPK1 mediates the growth of human malaria parasite

This study identifies 14-3-3I as a scaffold protein in Plasmodium falciparum and reveals its interaction with CDPK1, a key kinase, through phosphorylation-dependent binding, suggesting a potential target for antimalarial drug development.

Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like Calcium Dependent Protein Kinase 1, a multistage growth regulator of P. falciparum

The paper identifies a novel CDPK1 inhibitor from a molecular library that inhibits P. falciparum intra-erythrocytic growth in vitro.

Plasmodium falciparum growth is regulated by Sphingosine 1 phosphate produced by Host Erythrocyte Membrane Sphingosine kinase 1

This study inhibits host erythrocyte SphK-1 to reduce S1P levels, which halts Plasmodium falciparum growth and causes cell death by disrupting glycolysis.

Detection and identification of bacterial spp. from culture negative surgical site infection patients using molecular tool.

The paper identifies bacteria in culture-negative surgical site infections using 16S rRNA PCR, finding 54.63% of cases had viable but non-culturable, anaerobic, or unculturable bacteria.