12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes
A. Kulkarni, A. R. Pineros, S. Ibrahim, M. Hernandez-Perez, K. S. Orr, L. Glenn, M. Walsh, J. L. Nadler, M. A. Morris, S. A. Tersey, R. G. Mirmira, R. M. Anderson
This study shows that 12-LOX promotes islet inflammation and autoimmune diabetes by enhancing macrophage infiltration and migration via CXCR3.
bioRxiv · Jan 2, 2021Immunology