aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2 mediated SphK1-S1PR1-Akt signaling axis
O. Molinar-Inglis, C. A. Birch, D. Nicholas, M. Cisneros-Aguirre, A. Patwardhan, B. Chen, N. J. Grimsey, P. K. Gomez-Menzies, H. Lin, L. J. Coronel, M. A. Lawson, H. H. Patel, J. Trejo
This study identifies a novel β-arrestin-2-mediated signaling pathway that mediates aPC/PAR1's anti-apoptotic effects in endothelial cells.
bioRxiv · Mar 27, 2021Cell Biology