H. Lin

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

Spatial transcriptomics identifies novel Pseudomonas aeruginosa virulence factors

This study uses spatial transcriptomics to identify novel Pseudomonas aeruginosa virulence factors and host-pathogen interactions in ocular infection.

Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation

This study introduces lysineless HiBiT-RR and nLucK0 tagging systems to reduce degradation artifacts in monitoring protein degradation, showing HiBiT-RR retains sensitivity and nLucK0 shows different degradation patterns than nLucWT.

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

Hour-long, kilohertz sampling rate 3D single-virus tracking in live cells enabled by StayGold fluorescent protein fusions

This paper introduces StayGold fluorescent protein fusions to enable long-duration, high-speed 3D single-virus tracking in live cells.

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution

The paper characterizes a large collection of Bacteroidales isolates from the human gut, revealing genomic and metabolomic diversity and horizontal gene transfer across species.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

SIRT2-Mediated ACSS2 K271 Deacetylation Suppresses Lipogenesis Under Nutrient Stress

The paper shows that SIRT2 deacetylates ACSS2 at K271 under amino acid stress, leading to its degradation and reduced lipogenesis.

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

Tissue Tension and Strain as Indicators of Suction-mediated Cutaneous DNA Transfection: A Parametric Study

The paper evaluates cutaneous suction transfection efficacy using GFP expression in rats, identifying strain and tension as indicators for optimizing transfection protocols.

Phenotypic screening of covalent compound libraries identifies chloromethyl ketone antibiotics and MiaA as a new target

Synaptotagmin 7 C2 domains induce membrane curvature stress via electrostatic interactions and the wedge mechanism

This study investigates how Syt-7 C2 domains generate membrane curvature through electrostatic interactions and the wedge mechanism, using simulations and assays.

Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps

This study identifies genomic signatures of yolk loss in parasitoid wasps, showing independent Vg gene loss events and associated functional biases in related genes.

Exposure and resistance to lantibiotics impact microbiota composition and function

This study shows that lantibiotic resistance genes in gut bacteria affect microbiota composition and function, with implications for microbiome health and resistance strategies.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

NLRP3 Cys126 palmitoylation by ZDHHC7 Promotes Inflammasome Activation

This study identifies ZDHHC7-mediated palmitoylation of NLRP3 at Cys126 as critical for inflammasome activation, with implications for therapeutic targeting of inflammatory diseases.

LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat

This study identifies LEAFY and WAPO1 as regulators of spikelet number per spike and floret development in wheat through genetic and molecular interactions.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

ATP-release pannexin channels are gated by lysophospholipids

The paper identifies lysophospholipids as activators of pannexin channels, showing they trigger ATP and other metabolite release, and activate inflammasomes in human monocytes.

ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.

High-throughput single-cell sorting by stimulated Raman-activated cell ejection

This paper introduces a high-throughput single-cell sorting platform using stimulated Raman-activated cell ejection, achieving high yield and purity in sorting polymer beads, bacteria, fungi, and tissue sections.

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration

This study identifies circulating senescent myeloid cells as drivers of blood-brain barrier breakdown and neurodegeneration in LCH-ND.

TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

This study shows TRIP13 localizes to synapsed chromosomes and is a dosage-sensitive regulator of meiosis, with loss leading to sterility and meiotic defects.

Structure-Activity Relationship Studies of Novel Gut-derived Lantibiotics Against Human Gut Commensals

The paper characterizes six gut-derived nisin-like lantibiotics, evaluates their antimicrobial activity against pathogens and commensals, and identifies key residues affecting their activity.

Quantification of glutathione with high throughput live-cell imaging

This study quantifies glutathione dynamics in living cells using a reversible fluorescent probe, demonstrating its sensitivity and applicability in high-throughput imaging.

GIGANTEA accelerates wheat heading time through gene interactions converging on FLOWERING LOCUS T1

This study shows that GIGANTEA accelerates wheat heading time by interacting with genes in the flowering pathway, with effects dependent on photoperiod and vernalization.

miR-324 mediates bone homeostasis through the regulation of osteoblast and osteoclast differentiation and activity

This study shows miR-324 regulates bone homeostasis by controlling osteoblast and osteoclast activity, with its deletion causing increased bone mass and cartilage damage in OA and aging.

Dissecting components of the Campylobacter jejuni fetMP-fetABCDEF gene cluster in iron scavenging

This study investigates the role of the fetMP-fetABCDEF gene cluster in C. jejuni iron acquisition, showing that fetA-D are essential for growth under iron limitation and that FetE and FetF function redundantly as oxidoreductases.

Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence.

The paper identifies that longer inverted repeats in the flagellar switch region of C. difficile RT027 strains correlate with greater virulence and phenotypic heterogeneity in flagellar gene expression.