Author

L. Kaler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

E. Iverson· 4 shared M. A. Scull· 4 shared D. Song· 3 shared G. Duncan· 3 shared G. A. Duncan· 2 shared S. Bader· 2 shared A. Boboltz· 1 shared E. M. Engle· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

E. Iverson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mucus physically restricts influenza A viral particle access to the epithelium

L. Kaler, E. M. Engle, E. Iverson, A. Boboltz, M. A. Ignacio, M. Rife, M. A. Scull, G. Duncan

This study shows mucus traps influenza A virus through physical barriers, not just sialic acid binding, and synthetic hydrogels with similar structures can block infection.

bioRxiv · Aug 14, 2023Microbiology

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium

D. Song, E. Iverson, L. Kaler, M. A. Scull, G. A. Duncan

The paper investigates the roles of MUC5B and MUC5AC in mucociliary clearance using KO models and finds impaired transport when either mucin is absent.

bioRxiv · Mar 11, 2022Physiology

Machine Learning Informed Predictions of Nanoparticle Mobility and Fate in the Mucus Barrier

L. Kaler, K. Joyner, G. Duncan

This study uses machine learning to classify nanoparticle diffusion modes in mucus and predicts their transport and fate.

bioRxiv · Mar 4, 2022Bioengineering

Modeling airway dysfunction in asthma using synthetic mucus biomaterials

D. Song, E. Iverson, L. Kaler, S. Bader, M. A. Scull, G. A. Duncan

This paper develops a synthetic mucus biomaterial to model asthma-related airway dysfunction and shows it mimics key properties of native mucus in health and disease.

bioRxiv · Oct 16, 2020Bioengineering

Influenza A virus diffusion through mucus gel networks

L. Kaler, E. Iverson, S. Bader, D. Song, M. A. Scull, G. Duncan

This study quantifies influenza A virus diffusion through human airway mucus, finding that mesh structure, not neuraminidase activity, primarily influences virus mobility.

bioRxiv · Aug 14, 2020Biophysics