D. Song

Human erythroid progenitors express antigen presentation machinery

The paper identifies human erythroid progenitors as immune mediators expressing MHC class II machinery and interacting with T cells in the fetal liver.

Synthetic mucus barrier arrays as a nanoparticle formulation screening platform

This paper develops a synthetic mucus barrier array platform for high-throughput screening of nanoparticle formulations to improve mucosal drug delivery.

Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

ULK1 forms distinct oligomeric states and nanoscopic structures during autophagy initiation

This study uses single-molecule imaging to show ULK1 forms distinct clusters during autophagy initiation, with cluster size and composition correlating with autophagosome formation.

Photoswitchable binders enable temporal dissection of endogenous protein function

This paper introduces photoswitchable DARPins (psDARPins) for optical control of endogenous protein function, demonstrating their use in inhibiting ERK and Ras and studying EGFR to ERK signaling.

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

CTCF is essential for proper mitotic spindle structure and anaphase segregation

This study shows that CTCF is crucial for correct mitotic spindle structure and anaphase segregation, leading to abnormal nuclear morphology in interphase.

An alpaca-derived nanobody neutralizes the SARS-CoV-2 omicron variant

This paper identifies a nanobody that effectively neutralizes the SARS-CoV-2 Omicron variants BA.1 and BA.2, showing high affinity and pre-clinical promise.

Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Chitosan-Polyaniline Substrates Promotes Neural Priming

This study shows that electrical stimulation of hMSCs on soft conductive CS-g-PANI substrates increases neural markers and decreases glial markers, suggesting a neural-like phenotype.

Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson's disease-specific hepatocytes

This study uses patient-derived iPSCs to identify retinoids as potential therapeutics for Wilson's disease by rescuing ceruloplasmin secretion and reducing oxidative stress.

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.

A study of hyperelastic continuum models for isotropic athermal fibrous networks

This study evaluates four hyperelastic models for isotropic athermal fibrous networks, finding that affine and three-chain models accurately capture mechanical behavior under tension and shear, while others fail.

NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma

This study identifies NSUN2-mediated m5C modification as a regulator of hepatocellular carcinoma progression through oncogene expression and Ras signaling pathway modulation.

Identification of CD133+ Intercellsomes in Intercellular Communication to Offset Intracellular Signal Deficit

The paper identifies CD133+ intercellsomes as a mechanism for intercellular communication to compensate for intracellular signal deficits in stress conditions.

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium

The paper investigates the roles of MUC5B and MUC5AC in mucociliary clearance using KO models and finds impaired transport when either mucin is absent.

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

This study shows TMEM120A does not mediate poking- or stretch-induced currents and identifies a specific coenzyme A-binding site through cryo-EM structures.

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium

This study investigates RV-C15 replication in human airway epithelium, identifying the endoplasmic reticulum as the primary replication site and revealing cytopathic effects on epithelial function.

Membrane-Tethered Mucin 1 is Stimulated by Interferon in Multiple Cell Types and Antagonizes Influenza A Virus Infection in Human Airway Epithelium

This study investigates how MUC1 interacts with influenza A virus in human airway epithelium and shows that MUC1 expression increases during infection, potentially limiting viral spread.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state: multiscale measurements and computational modeling

This study investigates the P710R mutation in β-cardiac myosin, showing it causes hypercontractility by disrupting the super-relaxed state, using multiscale experiments and modeling.

Modeling airway dysfunction in asthma using synthetic mucus biomaterials

This paper develops a synthetic mucus biomaterial to model asthma-related airway dysfunction and shows it mimics key properties of native mucus in health and disease.

A torsion-based rheometer for measuring viscoelastic material properties

This paper introduces a low-cost, portable rheometer for measuring viscoelastic properties, suitable for educational and field use.

Influenza A virus diffusion through mucus gel networks

This study quantifies influenza A virus diffusion through human airway mucus, finding that mesh structure, not neuraminidase activity, primarily influences virus mobility.

Seminal plasma exosomes evoke calcium signal via CatSper channel to regulate human sperm function

This study shows that seminal plasma exosomes increase human sperm calcium levels via the CatSper channel, improving motility and offering potential clinical applications for asthenozoospermia.

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

Three-dimensional traction microscopy accounting for cell-induced matrix degradation

This paper introduces a computational method to quantify both cellular tractions and ECM degradation in 3D Traction Microscopy, showing that neglecting degradation leads to significant traction measurement errors.

Designing viscoelastic mucin-based hydrogels

This study designs mucin-based hydrogels with viscoelastic properties similar to native mucus using thiol-based cross-linking.

Hypertrophic cardiomyopathy mutations at the folded-back sequestered β-cardiac myosin S1-S2 and S1-S1 interfaces release sequestered heads and increase myosin enzymatic activity

This study shows HCM mutations at specific myosin interfaces increase accessible heads and myosin activity, contributing to hypercontractility.

Controlling load-dependent contractility of the heart at the single molecule level

This study measures the load-dependent detachment rate of human β-cardiac myosin at the single molecule level and shows it can be modulated by compounds and mutations.