The histone methyltransferase DOT1L is essential for humoral immune responses
L. Kealy, A. Di Pietro, L. Hailes, S. Scheer, L. Dalit, J. Groom, C. Zaph, K. L. Good-Jacobson
This study shows that DOT1L is essential for B cell development and humoral immune responses, as its deletion leads to impaired germinal center formation and reduced antibody production.
bioRxiv · Jun 19, 2020Immunology