Author

L. Hailes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. Zaph· 2 shared K. L. Good-Jacobson· 2 shared L. Dalit· 2 shared S. Scheer· 2 shared A. A. Sheikh· 1 shared A. Di Pietro· 1 shared A. Fletcher· 1 shared A. Zaini· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

C. Zaph

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Author profile →

3 papers

Recent·Most cited

Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

J. Polmear, L. Hailes, M. Olshansky, M. Rischmueller, E. L'Estrange-Stranieri, A. Fletcher, M. Hibbs, V. Bryant, K. Good-Jacobson

This study shows that inhibiting BMI-1 reduces antibody-secreting cells in autoimmune models, suggesting BMI-1 as a therapeutic target for antibody-mediated autoimmune diseases.

bioRxiv · Jul 27, 2023Immunology

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response

A. Zaini, L. Dalit, A. A. Sheikh, D. Thiele, Y. Zhang, J. Runting, G. Rodrigues, J. Ng, M. Bramhall, S. Scheer, L. Hailes, J. R. Groom, K. L. Good-Jacobson, C. Zaph

This study identifies distinct Tfh cell populations during chronic and acute helminth infections and shows their role in type 2 immune responses.

bioRxiv · Oct 20, 2021Immunology

The histone methyltransferase DOT1L is essential for humoral immune responses

L. Kealy, A. Di Pietro, L. Hailes, S. Scheer, L. Dalit, J. Groom, C. Zaph, K. L. Good-Jacobson

This study shows that DOT1L is essential for B cell development and humoral immune responses, as its deletion leads to impaired germinal center formation and reduced antibody production.

bioRxiv · Jun 19, 2020Immunology