Nonsteroidal anti-inflammatory drugs alter the microbiota and exacerbate Clostridium difficile colitis while dysregulating the inflammatory response
D. Maseda, J. P. Zackular, B. Trindade, L. Kirk, L. J. Crofford, P. D. Schloss, J. L. Roxas, V. K. Viswanathan, G. Vedantam, L. M. Rogers, M. K. Washington, E. P. Skaar, D. M. Aronoff
This study shows NSAIDs like indomethacin alter gut microbiota and worsen C. difficile colitis by disrupting PG metabolism, epithelial integrity, and immune responses in mice.
bioRxiv · Aug 14, 2018Microbiology