M. K. Washington

This study shows that NanS and TcsL work together to increase cytotoxicity and disease severity in a mouse uterine infection model.

This study shows eosinophils reduce esophageal squamous cell carcinoma by releasing reactive oxygen species and inhibiting IL-17 pathways.

This study shows that SMAD4 suppresses colitis-associated colon cancer by inhibiting CCL20/CCR6-mediated inflammation in mice.

This study investigates the role of glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins TcdA and TcdB during infection, showing both contribute to disease with distinct pathological outcomes.

This study shows MTG16 regulates colonic epithelial differentiation and tumorigenesis by repressing E protein transcription factors in mice and links its expression to IBD.

This study shows that Sprouty2 restricts intestinal tuft and goblet cell numbers via GSK3β-mediated IL-33 expression, with implications for inflammatory bowel disease.

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

This study uses purified recombinant C. difficile toxins in a mouse model to investigate their pathogenic mechanisms and tissue effects.

The paper shows that succinate from commensal bacteria promotes tuft cell development and reduces ileal inflammation in a mouse model of Crohn's disease.

This study shows NSAIDs like indomethacin alter gut microbiota and worsen C. difficile colitis by disrupting PG metabolism, epithelial integrity, and immune responses in mice.