Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal Tumors
S. Ye, D. Sharipova, M. Kozinova, L. Klug, J. D'Souza, M. G. Belinsky, K. J. Johnson, M. B. Einarson, K. Devarajan, Y. Zhou, S. Litwin, M. C. Heinrich, R. DeMatteo, M. von Mehren, J. Duncan, L. Rink
This study identifies Wee1 as a therapeutic target in combination with avapritinib for treating gastrointestinal stromal tumors (GIST) by analyzing kinome profiles and conducting functional assays.
bioRxiv · Jun 7, 2020Cancer Biology