Dissecting conformational rearrangements and allosteric modulation in metabotropic glutamate receptor activation
N. Lecat-Guillet, R. B. Quast, H. Liu, T. C. Moller, X. Rovira, S. Soldevilla, L. Lamarque, E. Trinquet, J. Liu, J.-P. Pin, P. Rondard, E. Margeat
The paper uses FRET sensors to study conformational changes in mGlu2 receptors, showing ligands modulate activation through multiple states.
bioRxiv · Jan 7, 2022 · PreprintBiophysics