H. Liu

The impact of transplant location on the gut microbiome and resistome in patients undergoing hematopoietic stem cell transplantation at home versus in the hospital

This study compares the gut microbiome and resistome of patients undergoing home versus hospital hematopoietic stem cell transplantation, finding no significant differences but noting confounding factors in secondary analyses.

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure

This study shows that macrophage-derived CCL24 worsens fibrosis and cardiac dysfunction in heart failure by activating fibroblasts through the CCR3 receptor.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

The fully activated open state of KCNQ1 controls the cardiac 'fight-or-flight' response

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

A new yeast-based bioreporter for simple, sensitive, and cost-effective detection of dioxin-like compounds

This study develops a yeast-based bioreporter, DnaSc, for sensitive and cost-effective detection of dioxin-like compounds and AhR agonists with a detection limit of 10 fM for TCDD.

Occurrence, risk assessment of antibiotics and antimicrobial resistance in Escherichia coli in typical rivers of Sichuan

This study assesses antibiotic and antimicrobial resistance in Escherichia coli from Sichuan rivers, finding high contamination and resistance rates, with specific antibiotics linked to ecological risk.

The Hippo/YAP Pathway Mediates the De-differentiation of Corneal Epithelial Cells into Functional Limbal Epithelial Stem Cells In Vivo

This study shows corneal epithelial cells can de-differentiate into functional limbal epithelial stem cells in vivo, mediated by the Hippo/YAP pathway, offering a new approach for treating limbal stem cell deficiency.

Identification of a gene expression signature of vascular invasion and recurrence in stage I lung adenocarcinoma via bulk and spatial transcriptomics

Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease

This study identifies mutation and transcriptional state compatibility in Ph+ ALL MRD, showing that targeting these interactions can overcome BCR::ABL1 independence and improve MRD monitoring.

Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage

The paper analyzes gene family evolution across nearly all known Saccharomycotina yeast species, finding distinct evolutionary patterns with gene loss linked to metabolic and genomic changes.

Protein Editing using a Concerted Transposition Reaction

This paper introduces a method to replace internal protein regions in vitro using split inteins, enabling efficient protein semisynthesis under native folding conditions.

Necessity and Impact of Specialization of Large Foundation Model for Medical Segmentation Tasks

This study evaluates MedSAM and LiteMedSAM for medical image segmentation, finding that off-the-shelf performance is poor but specialized fine-tuning significantly improves accuracy.

Mitochondrial DNA is a sensitive surrogate and oxidative stress target in oral cancer cells

This study develops a method to quantify mtDNA damage, repair, and copy number changes in oral cancer cells under oxidative stress and finds differential responses compared to normal cells.

A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.

Interferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System

This study shows interferon induces ADP-ribosylation in p62 bodies via PARP14, requiring ubiquitin activation and proteasome activity.

Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites

This study uses molecular modeling and simulations to show that N-linked glycans on Nav channel alpha-subunits may block beta-subunit Ig-domain binding and influence channel clustering.

Clade-defining mutations in human H1N1 hemagglutinin protein from 2021-2023 have opposing effects on in vitro fitness and antigenic drift

This study identifies clade-defining mutations in H1N1 hemagglutinin that improve viral fitness but reduce neutralization by vaccine-induced antibodies, revealing an evolutionary trade-off between replication and immune evasion.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Circadian rhythms mediate malaria transmission potential

The paper shows that mosquito salivary gland and sporozoite gene expression cycles with the day-night rhythm, affecting malaria transmission.

Topoisomerase I is an Evolutionarily Conserved Key Regulator for Satellite DNA Transcription

This study identifies Topoisomerase I as a conserved regulator of satellite DNA transcription across species, showing its role in centromere function and DNA damage response.

Heterogeneous local structures of the microtubule lattice revealed by cryo-ET and non-averaging analysis

The paper uses cryo-ET and non-averaging analysis to reveal heterogeneous local structures of microtubules, showing polymerizing and depolymerizing ends share similar lattice spacing but differ in twisting.

MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics

The paper introduces MIPDB, a maize image-phenotype database with multi-angle and multi-time images, providing a high-quality dataset for deep learning-based phenomics research.

Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level

This paper introduces a single-molecule stretching assay to detect DNA-intercalating agents from microorganisms, identifying two strains and three compounds with anti-cancer activity.

3D bioprinting of Liver Microenvironment Model Using Photocrosslinkable Decellularized Extracellular Matrix based Hydrogel

This paper develops a photocrosslinkable liver decellularized extracellular matrix hydrogel for 3D bioprinting, showing enhanced liver cell proliferation and function.

Cure or Curse? Simulation Indicates that Microbes Proliferate under Disinfection Measures in the Space Station

This study simulates microbial proliferation in the space station under disinfection measures and finds that factors like low-dose ionizing radiation, dilution, and quaternary ammonium compound can synergistically promote microbial growth.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

Hepatitis E virus infection upregulates ING5 expression in vitro and vivo

This study shows that HEV infection increases ING5 expression in both animal models and human cells, suggesting a potential role in HEV pathogenesis.