L. Miele

The efficacy of CB-103, a first-in-class transcriptional Notch inhibitor, in preclinical models of breast cancer

This paper evaluates the efficacy and safety of CB-103, a Notch inhibitor, in preclinical breast cancer models, showing synergistic effects with existing therapies.

Targeting Cblb-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cells responses

This study identifies a novel immunosuppressive pathway involving Cbl-b-mediated Notch1 degradation and shows that targeting this axis enhances CD8+ T-cell responses and anti-cancer immunity.

Evolutionary epidemiology consequences of trait-dependent control of heterogeneous parasites

This study develops a model to explore how trait-dependent parasite control strategies affect disease dynamics and evolution, showing optimal treatment depends on application levels.

Redundancy-selection trade-off in phenotype-structured populations

The paper examines how redundancy-selection trade-offs affect phenotype-structured populations, showing that neutral contributions to fitness cannot be captured by effective formulations and depend on landscape geometry.

Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor

This study evaluates deacetylase inhibitors in metaplastic breast carcinoma using multiple preclinical models, finding they reduce metastasis and synergize with chemotherapy.