Cancer BiologybioRxiv
Targeting Cblb-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cells responses
G. Monticone, F. Csibi, S. Leit…·L. Miele
This study identifies a novel immunosuppressive pathway involving Cbl-b-mediated Notch1 degradation and shows that targeting this axis enhances CD8+ T-cell responses and anti-cancer immunity.
DOI 10.3389/fimmu.2022.987298