T. Chang

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Fraction of copy-number alterations significantly predicts survival following immunotherapy in a few cancers

The paper reanalyzes data to assess if tumor aneuploidy score or related metrics predict immunotherapy survival, finding only limited predictive power in a few cancers.

Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection

This study compares SARS-CoV-2 infection outcomes in immunocompetent and immunocompromised hamsters, finding that histopathological changes better predict disease severity than viral load or antibody levels.

WY14643 Increases Herpesvirus Replication Independent of PPARα Expression and Inhibits IFNβ Production

This study shows that PPAR agonists like WY14643 increase herpesvirus replication and inhibit IFNβ production, independent of PPARα expression.

Widespread sex ratio polymorphism in Caenorhabditis nematodes

The paper examines sex ratio polymorphism across 23 Caenorhabditis nematode species, finding that 12 species show strain-level variation, and challenges the sperm competition model as the sole explanation for biased sex ratios.

Single-molecule Mechanical Analysis of Strand Invasion in Human Telomere DNA

This study uses magnetic tweezers to form telomeric D-loops and shows that displaced DNA folds into G-quadruplexes, providing insight into telomere structure and potential therapeutic targets.

Arthropods and the evolution of RNA viruses

The paper identifies over 1400 new RNA viruses from arthropods, revealing their role in RNA virus evolution and co-evolution with hosts.

Th2 Cytokine Modulates Herpesvirus Reactivation in a Cell Type Specific Manner

This study shows that IL-4 induces MHV68 reactivation in macrophages but not B cells, indicating cell-type specific regulation of herpesvirus reactivation.

Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor

This study evaluates deacetylase inhibitors in metaplastic breast carcinoma using multiple preclinical models, finding they reduce metastasis and synergize with chemotherapy.

Metabolic Control of Viral Infection through PPAR-α Regulation of STING Signaling

This study shows that PPAR-α activation increases herpesvirus replication, suppresses type I interferon, and inhibits STING signaling through ROS.

Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression

This paper uses single-cell analysis to reveal heterogeneity in gammaherpesvirus gene expression across different infection stages.