Author

L. Penengo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Okonska· 1 shared A. R. Chaudhuri· 1 shared E. Felley-Bosco· 1 shared E. Smit· 1 shared I. Van der Meulen-Muileman· 1 shared M. Blijlevens· 1 shared M. Ronner· 1 shared P. Das· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Okonska

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2 papers

Recent·Most cited

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

L. Penengo, U. Biswas, R. N. Moro, S. S. Kharat, P. Das, A. R. Chaudhuri, S. K. Sharan

This study shows interferon (IFN) improves replication fork stability and cell survival in BRCA-defective cells through ISG15, revealing a new mechanism of drug resistance linked to BRCAness.

bioRxiv · Mar 16, 2023 · PreprintCancer Biology

Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy

A. Okonska, S. Buehler, V. Rao, M. Ronner, M. Blijlevens, I. Van der Meulen-Muileman, R. de Menezes, E. Smit, W. Weder, R. Stahel, L. Penengo, V. van Beusechem, E. Felley-Bosco

The paper identifies BAP1's role in regulating RRM2 during replication stress, showing that BAP1 loss increases chemoresistance to ribonucleotide reductase inhibitors in mesothelioma cells.

bioRxiv · Jul 31, 2018Cancer Biology