P. Das

Suppression of miRs-497/195 axis possibly confers endocrine therapy resistance via elevated expression of FLT4 and the noncoding RNA MIR503HG

The paper identifies miR-497/195 suppression as a mechanism of endocrine therapy resistance in breast cancer, linking it to elevated FLT4 and MIR503HG expression through RNA-seq and ceRNA network analysis.

Conformational dynamics associated with remote residues regulate the kinetic properties of homologous glutamate dehydrogenases (GDHs)

This study identifies remotely located residues and conformational dynamics as regulators of kinetic properties in homologous glutamate dehydrogenases.

Node Features of Chromosome Structure Network and Their Connections to Genome Annotation

The paper investigates network properties of chromosome structure networks derived from Hi-C data and their connections to genome annotations, finding that semi-local properties better characterize biological features than local or diffusive features.

Guggulsterone Enhances NKX3.1 Expression and Induces Apoptosis in Prostate Cancer Cells: Implications for Chemoprevention

This study shows Guggulsterone induces apoptosis in prostate cancer cells by increasing NKX3.1 expression and stabilizing its mRNA and protein, suggesting it as a potential chemoprevention target.

Apobec-Mediated Retroviral Hypermutation In Vivo is Dependent on Mouse Strain

This study shows that Rem protein in B6 mice affects tumorigenesis independently of Apobec-mediated proviral hypermutation, with TBLV-SD causing more tumors than TBLV-WT.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex

This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.

Heterogeneous identity, stiffness and growth characterise the shoot apex of Arabidopsis stem cell mutants

The paper investigates clavata mutant shoot apices in Arabidopsis, finding mechanical and functional heterogeneities that contribute to meristem overgrowth and buckling.

Landing the 'Tiger of Rivers': Understanding Recreational Angling of Mahseers in India using YouTube Videos

The paper analyzes YouTube videos of mahseer angling in India to assess recreational angling patterns and conservation implications.

Discovery & Evaluation of novel fluorescence molecules for selective recognition of G-quadruplexes structure

This study identifies and evaluates novel chroman derivatives and their borondifluoride complexes as selective G-quadruplex binders through in vitro and cellular assays.

Discovery of novel G-quadruplex stabilizing compounds from medicinal plant & Evaluates their cellular toxicity

This study identifies two non-toxic G-quadruplex stabilizing compounds from medicinal plants and evaluates their cellular toxicity.

Calcimycin mediates apoptosis in Breast and Cervical cancer cells by inducing intracellular calcium levels in a P2RX4-dependent manner

This study shows calcimycin induces apoptosis in breast and cervical cancer cells by increasing intracellular calcium levels via P2RX4 and p38 MAPK pathways.

Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

This study shows calcineurin inhibition in C. elegans extends lifespan by causing defecation defects that mimic calorie restriction and activate nuclear hormone signaling.

Small Interactor of PKD2 (SIP), a novel PKD2-related single-pass transmembrane protein, is required for proteolytic processing and ciliary import of Chlamydomonas PKD2

This study identifies SIP as a novel PKD2-interacting protein essential for PKD2 proteolytic processing and ciliary import in Chlamydomonas, affecting ciliary function and motility.

Changes in Cortical Directional Connectivity during Difficult Listening in Younger and Older Adults

The paper uses NLGC on MEG data to analyze directional cortical connectivity during speech listening in noise, finding age-related and condition-related changes in connectivity patterns.

Amorphous calcium phosphate-coated surfaces as a model for bone microenvironment in prostate cancer

The paper develops a cost-effective method to coat cell culture vessels with amorphous calcium phosphate to model the bone microenvironment and shows its effect on prostate cancer cell survival.

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

This study shows interferon (IFN) improves replication fork stability and cell survival in BRCA-defective cells through ISG15, revealing a new mechanism of drug resistance linked to BRCAness.

SifA SUMOylation governs Salmonella intracellular survival via modulation of lysosomal function

This study shows that SUMOylation of SifA in Salmonella Typhimurium is essential for intracellular survival by modulating lysosomal function and SIF formation.

Discovery of highly potent small molecule pan-coronavirus fusion inhibitors

This paper discovers and characterizes NBCoV63, a potent small molecule inhibitor effective against multiple SARS-CoV-2 variants and other coronaviruses.

High resolution cryo-EM structures of two potently SARS-CoV-2 neutralizing monoclonal antibodies of same donor origin that vary in neutralizing Omicron variants

The paper presents high-resolution cryo-EM structures of two SARS-CoV-2 neutralizing mAbs from the same donor, showing differences in their binding to Omicron variants and conformational changes in the spike protein.

Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

Captivity-induced behaviour and spatial learning abilities in an enigmatic, aquifer-dwelling blind eel, Rakthamichthys digressus

This study examines how captivity affects behavior and spatial learning in the blind eel Rakthamichthys digressus, finding altered behaviors but no change in behavioral syndromes or spatial learning ability.

Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

Alterations in chromosome spatial compartmentalization classify prostate cancer progression

The paper uses Hi-C data to show that changes in chromatin compartmentalization classify prostate cancer progression, with specific gene clusters switching compartments and contributing to disease progression.

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

Better expression profile of CD8 and CD4 gene in uterus of pregnant ewe in comparison to non-pregnant - a novel report

The paper reports higher CD8 and CD4 gene expression in the uterus of pregnant ewes compared to non-pregnant ewes, suggesting their potential as markers for pregnancy detection in sheep.

Bioremediation Potential of Select Bacterial Species for the Neonicotinoid Insecticides, Thiamethoxam and Imidacloprid

This study evaluates the bioremediation potential of six bacterial species for the neonicotinoid insecticides thiamethoxam and imidacloprid, finding that some species significantly reduce THM concentrations in aqueous media.

Is Boldness in Climbing Perch (Anabas testudineus) Sensitive to the Apparatus Used for Measurement?

This study examines how different apparatus designs affect boldness measurements in climbing perch, finding significant variation in boldness based on experimental setup.

MiR-146a-dependent regulation of CD24/AKT/β-catenin axis drives stem cell phenotype in oral squamous cell carcinoma

This study shows miR-146a promotes stemness in oral squamous cell carcinoma by regulating the CD24/AKT/β-catenin axis, enhancing tumorigenic potential.