Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization
M. Balbach, L. Ghanem, T. Rossetti, N. Kaur, C. Ritagliati, J. Ferreira, D. Krapf, L. Puga, C. Santi, J. N. Hansen, D. Wachten, M. Fushimi, P. T. Meinke, J. Buck, L. R. Levin
This study shows that inhibiting soluble adenylyl cyclase (sAC) in human sperm prevents key functions needed for fertilization, suggesting sAC inhibitors as potential non-hormonal contraceptives.
bioRxiv · Apr 27, 2021Pharmacology & Toxicology