D. Wachten

Cytosolic sodium accumulation is a common danger signal triggering endocytic dysfunction and NLRP3 inflammasome activation

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

Opposing roles of resident and infiltrating immune cells in the defence against Legionella longbeachae via IL-18R/IFN-γ/ROS axis

This study identifies opposing roles of tissue-resident alveolar macrophages and infiltrating neutrophils/monocyte-derived cells in controlling Legionella longbeachae infection via the IL-18R/IFN-γ/ROS pathway.

BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue

This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.

AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

AdipoQ quantifies adipocyte morphology and function in tissues and in vitro using an open-source ImageJ plugin for automated analysis.

Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function.

The paper identifies a cold-inducible truncated Adcy3 mRNA isoform, Adcy3-at, which acts as a rheostat to regulate brown fat function by limiting cAMP activity during obesity.

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

This study shows that inhibiting soluble adenylyl cyclase (sAC) in human sperm prevents key functions needed for fertilization, suggesting sAC inhibitors as potential non-hormonal contraceptives.

CiliaQ - a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images

CiliaQ provides an open-source tool for automated ciliary morphology and fluorescence analysis in 2D, 3D, and 4D images, offering comprehensive and reproducible results.

Multifocal imaging for precise, label-free tracking of fast biological processes in 3D

This paper introduces a new open-source 3D reconstruction algorithm for multifocal imaging, enabling label-free, high-speed tracking of fast biological processes in 3D.

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

This study develops a nanobody-based method to target optogenetic tools to the primary cilium, enabling analysis of ciliary signaling and function in vitro and in vivo.

SpermQ - a simple analysis software to comprehensively study flagellar beating and sperm steering

SpermQ is a software tool that quantifies sperm flagellar beating and steering, enabling detailed analysis of motility patterns from time-lapse microscopy images.