Author

D. Krapf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Assay:CUT&Tag· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

M. G. Buffone· 4 shared A. Darszon· 3 shared G. M. Luque· 3 shared X. Xu· 3 shared C. Ritagliati· 2 shared C. Stival· 2 shared M. G. Gervasi· 2 shared A. Arenas-Hernandez· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCell Biology

M. G. Buffone

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Author profile →

5 papers

Recent·Most cited

The sodium-proton exchangers sNHE and NHE1 control plasma membrane hyperpolarization in mouse sperm.

A. G. Novero, P. T. Rodriguez, J. L. de la Vega Beltran, L. J. Schiavi-Ehrenhaus, G. M. Luque, M. Carruba, C. Stival, I. Gentile, C. Ritagliati, C. M. Santi, T. Nishigaki, D. Krapf, M. G. Buffone, A. Darszon, C. L. Trevino, D. Krapf

This study identifies Na+/H+ exchangers as key regulators of plasma membrane hyperpolarization in mouse sperm, challenging the role of PKA and revealing a novel pathway involving cAMP, calcium, and SLO3 K+ channels.

bioRxiv · Mar 4, 2024Cell Biology

Reorganization of the Flagellum Scaffolding Induces a Sperm Standstill During Fertilization

M. Jablonski, G. M. Luque, M. Gomez-Elias, C. Sanchez-Cardenas, X. Xu, J. L. de la Vega-Beltran, G. Corkidi, A. Linares, V. Abonza, A. Arenas-Hernandez, M. D. P. Ramos-Godinez, A. Lopez-Saavedra, D. Krapf, D. Krapf, A. Darszon, , M. G. Buffone

This study shows that reorganization of the flagellum's F-actin network during sperm-egg fusion leads to midpiece contraction and motility cessation.

bioRxiv · Jun 22, 2023Cell Biology

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

M. Balbach, L. Ghanem, T. Rossetti, N. Kaur, C. Ritagliati, J. Ferreira, D. Krapf, L. Puga, C. Santi, J. N. Hansen, D. Wachten, M. Fushimi, P. T. Meinke, J. Buck, L. R. Levin

This study shows that inhibiting soluble adenylyl cyclase (sAC) in human sperm prevents key functions needed for fertilization, suggesting sAC inhibitors as potential non-hormonal contraceptives.

bioRxiv · Apr 27, 2021Pharmacology & Toxicology

Cdc42 activity is essential for the interplay between cAMP/PKA pathway and CatSper function

G. M. Luque, X. Xu, A. Romarowski, M. G. Gervasi, G. Orta, J. De la Vega-Beltran, C. Stival, N. Gilio, T. Dalotto-Moreno, D. Krapf, P. E. Visconti, D. Krapf, A. Darszon, M. G. Buffone

The paper shows that Cdc42 activity is crucial for the interaction between the cAMP/PKA pathway and CatSper function in sperm, affecting Ca2+ transport and fertilization.

bioRxiv · Aug 24, 2020 · PreprintCell Biology

The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure

M. G. Gervasi, X. Xu, B. Carbajal-Gonzalez, M. G. Buffone, P. Visconti, D. Krapf

The paper uses STORM to reveal different actin structures in mouse sperm flagella, including a double-helix in the midpiece.

bioRxiv · Jan 22, 2018Cell Biology